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Cagrilintide is a long-acting synthetic peptide analogue of human amylin, engineered for dual activation of amylin and calcitonin receptors (DACRA). It is designed with specific amino acid substitutions and N-terminal acylation (a fatty acid side chain) to enhance metabolic stability and prolong its half-life.
In research models, Cagrilintide is studied for its role in appetite regulation, gastric emptying, and energy balance, acting primarily through central and peripheral pathways involved in metabolic control. It remains strictly a research compound, not intended for therapeutic or dietary use.
Molecular Formula: C₃₃H₅₇N₁₁O₉
Molecular Weight: 751.9 g/mol
Synonyms:
Selank
TP-7
Thr-Lys-Pro-Arg-Pro-Gly-Pro
CAS Number: 129954-34-3
PubChem CID: 11765600
Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, designed to mimic tuftsin and modulate neurochemical pathways like GABA, serotonin, and dopamine.
Research suggests that N-Acetyl Selank may have several beneficial effects, including:
Anxiety and Stress Reduction:
Shown to reduce symptoms of generalized anxiety disorder (GAD) with comparable efficacy to benzodiazepines.
Memory & Learning Enhancement:
Enhances memory consolidation and learning capacity, even restoring cognitive functions affected by damage to catecholaminergic systems.
Immune System Modulation:
Modulates cytokine levels, particularly interleukin-6 (IL-6), and helps shift the balance between Th1/Th2 responses, supporting immune function.
Neuroprotective Properties:
Affects gene expression related to GABA, dopamine, and serotonin systems, potentially providing neuroprotection and enhancing neurotransmission.
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